History
TAP tagging was invented by a research team working in the European Molecular Biology Laboratory at late 1990s (Rigaut et al., 1999, Puig et al.,2001) and proposed as a new tool for proteome exploration. It was used by the team to characterize several protein complexes (Rigaut et al., 1999, Caspary et al. 1999, Bouveret et al., 2000, Puig et al., 2001). The first large-scale application of this technique was in 2002, in which the research team worked in collaboration with scientists of the proteomics company Cellzome to develop a visual map of the interaction of more than 230 multi-protein complexes in a yeast cell by systematically tagging the TAP tag to each protein.
Read more about this topic: Tandem Affinity Purification
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