Taft Plots in QSAR
The Taft equation is often employed in biological chemistry and medicinal chemistry for the development of quantitative structure activity relationships (QSAR). In a recent example, Sandri and co-workers have used Taft plots in studies of polar effects in the aminolysis of β-lactams. They have looked at the binding of β-lactams to a poly(ethyleneimine) polymer, which functions as a simple mimic for human serum albumin (HSA). The formation of a covalent bond between penicillins and HSA as a result of aminolysis with lysine residues is believed to be involved in penicillin allergies. As a part of their mechanistic studies Sandri and co-workers plotted the rate of aminolysis versus calculated σ* values for 6 penicillins and found no correlation, suggesting that the rate is influenced by other effects in addition to polar and steric effects
Read more about this topic: Taft Equation
Famous quotes containing the words taft and/or plots:
“The diplomacy of the present administration has sought to respond to the modern idea of commercial intercourse. This policy has been characterized as substituting dollars for bullets.”
—William Howard Taft (1857–1930)
“Nothing aids which may not also injure us.
Fire serves us well, but he who plots to burn
His neighbor’s roof arms his hands with fire.”
—Ovid (Publius Ovidius Naso)