Safety
No official studies have been conducted on its effects on humans. Though its effects are not well-documented, extremely large doses may cause negative effects that are in general not noted in cannabis users, such as increased agitation and vomiting. Professor John W. Huffman, who first synthesised many of the cannabinoids used in synthetic cannabis, is quoted as saying, "People who use it are idiots." "You don't know what it's going to do to you." A user who consumed 3 g of Spice Gold every day for several months showed withdrawal symptoms, similar to those associated with withdrawing from the use of narcotics. Doctors treating the user also noted that his use of the product showed signs associated with addiction. One case has been reported wherein a user, who had previously suffered from cannabis-induced recurrent psychotic episodes, suffered reactivation of his symptoms after using Spice. Psychiatrists treating him have suggested that the lack of an antipsychotic chemical, similar to cannabidiol found in natural cannabis, may make synthetic cannabis more likely to induce psychosis than natural cannabis.
Studies are currently available which suggest an association between synthetic cannabinoids and psychosis. Physicians should be aware that the use of synthetic cannabinoids can be associated with psychosis and investigate possible use of synthetic cannabinoids in patients with inexplicable psychotic symptoms. Also, people with risk factors for psychosis should be counseled against using synthetic cannabinoids.
Myocardial infarction (heart attacks) were associated with the use of the synthetic cannabinoid K2. Also, convulsions were associated with the use of a synthetic cannabinoid product.
Read more about this topic: Synthetic Cannabis
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—Henry David Thoreau (1817–1862)