Synaptic Gating - Inhibition - Role in Working Memory

Role in Working Memory

Gating mechanisms in the basal ganglia have been linked to our ability to filter irrelevant information and access relevant information from working memory. In this instance, the gatekeeping function is the responsibility of the thalamus. It opens the gate between two areas in the cortex, allowing for the influence of stimuli in working memory. The thalamus, however, is tonically inhibited by the basal ganglia. Activation within the basal ganglia will allow for the disinhibition of the thalamus and thus, the opening of the gate.

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