The term SXC can refer to:
- stock.xchng - A photo sharing website
- SXC - An abbreviation commonly used on Internet chat rooms and SMS Messaging, meaning Sexy.
- SXC - An abbreviation commonly used for the Southern Cross Cable submarine cable system
- .sxc - a computer filename extension used by OpenOffice.org XML spreadsheet file format
- SXC - Space Expedition Corporation, a company promoting sub-orbital space tourism