Research and Drug Development
Sugen went public in October 1994 (NASDAQ: SUGN), and shortly after filed its first Investigational New Drug (IND) application, for a PDGFR inhibitor, SU101. This failed clinically, but was followed by a different series of compounds that inhibited VEGFR kinases (involved in angiogenesis) as well as PDGFR and Kit. Of these, SU5416 (Semaxanib) and SU6668 went into clinical trials for colon cancer in 1999. SU5416 proceeded to Phase 3 trials, while the follow-on compound, SU11248 (Sunitinib) was later approved for human use, and a related compound SU11654 (Toceranib) was approved for canine tumors.
Sugen was funded though a number of collaborative research programs with companies including ASTA Medica (pan-Her and Raf programs), Allergan (opthalmic angiogenesis inhibition), Zeneca (EGFR and cancer), and Amgen all of which took equity stakes in the company, and Taiho (cancer). Conversely, Sugen was an investor in and collaborator with Selectide for the development of peptide kinase inhibitors.
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