Succinic Acid - Biochemistry

Biochemistry

Succinate is an intermediate in the citric acid cycle and is capable of donating electrons to the electron transport chain by the reaction:

succinate + FAD → fumarate + FADH₂.

Click on genes, proteins and metabolites below to link to respective articles.

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This conversion is catalysed by the enzyme succinate dehydrogenase (or complex II of the mitochondrial ETC). The complex is a 4 subunit membrane-bound lipoprotein which couples the oxidation of succinate to the reduction of ubiquinone. Intermediate electron carriers are FAD and three 2Fe-2S clusters part of subunit B.