Relationship With Other Circumventricular Organs
Other circumventricular organs are the area postrema in the brainstem and the organum vasculosum of the lamina terminalis (OVLT).
The OVLT and the SFO are both strongly interconnected with the nucleus medianus, and together these three structures comprise the so called "AV3V" region - the region anterior and ventral to the third ventricle. The AV3V region is very important in the regulation of fluid and electrolyte balance, by controlling thirst, sodium excretion, blood volume regulation, and vasopressin secretion.
The SFO is outside the blood–brain barrier, and so neurons in this region can respond to factors that are present in the systemic circulation. The circumventricular organs express high density of Glucagon-like peptide 1 (GLP-1)receptors and participate in the central regulation of energy intake.
Read more about this topic: Subfornical Organ
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