Stress Granule - Formation of Stress Granules

Formation of Stress Granules

Environmental stress triggers a series of signals which eventually lead to formation of stress granules. Early on, it involves phosphorylation of eukaryotic translation initiation factor eIF2α. Further downstream, prion-like aggregation of the protein TIA-1 leads to the formation of stress granules. The term prion-like is used because aggregation of TIA-1 is concentration dependent, inhibited by chaperones, and because the aggregates are resistant to proteases. It has also been proposed that microtubules play a role in the formation of stress granules, maybe by transporting granule components. This hypothesis is based on the fact that disruption of microtubules with the chemical nocodazole blocks the appearance of the granules.

Read more about this topic:  Stress Granule

Famous quotes containing the words formation of, formation and/or stress:

    Out of my discomforts, which were small enough, grew one thing for which I have all my life been grateful—the formation of fixed habits of work.
    Elizabeth Stuart Phelps (1844–1911)

    It is because the body is a machine that education is possible. Education is the formation of habits, a superinducing of an artificial organisation upon the natural organisation of the body.
    Thomas Henry Huxley (1825–1895)

    A society which is clamoring for choice, which is filled with many articulate groups, each urging its own brand of salvation, its own variety of economic philosophy, will give each new generation no peace until all have chosen or gone under, unable to bear the conditions of choice. The stress is in our civilization.
    Margaret Mead (1901–1978)