Stress Granule - Formation of Stress Granules

Formation of Stress Granules

Environmental stress triggers a series of signals which eventually lead to formation of stress granules. Early on, it involves phosphorylation of eukaryotic translation initiation factor eIF2α. Further downstream, prion-like aggregation of the protein TIA-1 leads to the formation of stress granules. The term prion-like is used because aggregation of TIA-1 is concentration dependent, inhibited by chaperones, and because the aggregates are resistant to proteases. It has also been proposed that microtubules play a role in the formation of stress granules, maybe by transporting granule components. This hypothesis is based on the fact that disruption of microtubules with the chemical nocodazole blocks the appearance of the granules.

Read more about this topic:  Stress Granule

Famous quotes containing the words formation of, formation and/or stress:

    That for which Paul lived and died so gloriously; that for which Jesus gave himself to be crucified; the end that animated the thousand martyrs and heroes who have followed his steps, was to redeem us from a formal religion, and teach us to seek our well-being in the formation of the soul.
    Ralph Waldo Emerson (1803–1882)

    I want you to consider this distinction as you go forward in life. Being male is not enough; being a man is a right to be earned and an honor to be cherished. I cannot tell you how to earn that right or deserve that honor. . . but I can tell you that the formation of your manhood must be a conscious act governed by the highest vision of the man you want to be.
    Kent Nerburn (20th century)

    Anyone who wishes to combine domestic responsibilities and paid employment with the least stress and most enjoyment might start by pondering this paradox: the first step to better functioning is to stop blaming herself for not functioning well enough.
    Faye J. Crosby (20th century)