A straitjacket is a garment used for restraint.
Straitjacket may also refer to:
- Strait-Jacket, a 1964 Columbia Pictures film starring Joan Crawford
- Straight-Jacket, a 2004 gay-themed romantic comedy film
- Strait Jacket, a 2007 Japanese animated film
- Strait Jackets, a punk rock band from Tampa, Florida
- Straitjacket (comedy duo), a comedy team from England
- Strait Jacket, a novel series by IchirÅ Sakaki
- Los Straitjackets, an American instrumental band