Stibophen - Mechanism of Action

Mechanism of Action

It inhibits phosphofructokinase enzyme,necessary for glycolysis by combining with the sulfhydryl (SH) on the enzyme,once glycolysis is inhibited, the worms become paralyzed and lose their hold on the wall of mesentric veins and undergoes hepatic shift,die and phagocytosed by hepatic cells.


Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)
Antiplatyhelmintic agents
Antitrematodals
(schistosomicides)
Binds tubulin
  • benzimidazole
    • Triclabendazole#
AI
  • phosphonic acid
    • Metrifonate
Other/unknown
  • quinoline
    • Praziquantel#
    • Oxamniquine#
  • phenol
    • Bithionol
  • thiazole
    • Niridazole
  • arylsulfonate
    • Stibophen
Anticestodals
(taeniacides)
Binds tubulin
  • benzimidazole
    • Albendazole#
Other/unknown
  • salicylanilide
    • Niclosamide#
  • aminoacridine
    • Quinacrine
  • butyrophenone
    • Desaspidin
  • chlorophenol
    • Dichlorophen
Antinematodal agents
(including
macrofilaricides)
Binds tubulin
  • benzimidazole
    • Mebendazole#
    • Albendazole#
    • Thiabendazole
    • Fenbendazole
    • Ciclobendazole
    • Flubendazole
Glutamate-gated chloride channel, GABA receptor
  • avermectins
    • Abamectin
    • Doramectin
    • Emamectin
    • Ivermectin
    • Selamectin
  • milbemycins
    • Moxidectin
    • Milbemycin oxime
NMDA
  • tetrahydropyrimidine
    • Pyrantel#
    • Pyrantel pamoate
    • Oxantel
Other/unknown
  • piperazine
    • Piperazine
    • Diethylcarbamazine#
  • thiazole
    • Levamisole#
  • quinolinium
    • Pyrvinium
  • benzylammonium
    • Bephenium
  • naphthalenesulfonate
    • Suramin#
  • Tribendimidine
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

M: IFT

helm, arth (acar)

helm, arth (lice), zoon

helm, arth


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