Isoforms
Mammalian genomes have two separate SREBP genes (SREBF1 and SREBF2):
- SREBP-1 expression produces two different isoforms, SREBP-1a and -1c. These isoforms differ in their first exons owing to the use of different transcriptional start sites for the SREBP-1 gene. SREBP-1c was also identified in rats as ADD-1. SREBP-1c is responsible for regulating the genes required for de novo lipogenesis.
- SREBP-2. SREBP-2 regulates the genes of cholesterol metabolism.
Read more about this topic: Sterol Regulatory Element-binding Protein