Yeast
In yeast, acyl-CoA:sterol acyltransferase (ASAT) is functionally equivalent to ACAT. Although studies in vitro and in yeast suggest that the acyl-CoA binding protein (ACBP) may modulate long-chain fatty acyl-CoA (LCFA-CoA) distribution, the physiological function in mammals is unresolved. Recent research suggests that ACBP expression may play a role in LCFA-CoA metabolism in a physiological context.
In S. cerevisiae, the accumulation of ergosteryl esters accompanies entry into the stationary phase and sporulation. Researchers have identified two genes in yeast, SAT-1 and SAT-2, that encode for the different isozymes of ASAT. In yeast, SAT-1 is the major catlytic isoform. Mitotic cell growth and spore germination are not compromised when these genes are deleted, but diploids that are homozygous for a SAT-1 null mutation exhibit a decrease in sporulation efficiency.
Read more about this topic: Sterol O-acyltransferase
Famous quotes containing the word yeast:
“Do you not know that a little yeast leavens the whole batch of dough?”
—Bible: New Testament, 1 Corinthians 5:6.
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—Carmen McRae (b. 1922)