Discontinuation of SNRIs
SNRIs affect both reuptake inhibition of serotonin and norepinephrine. The two mostly widely prescribed SNRIs are venlafaxine and duloxetine. To these has been added desvenlafaxine. In addition, the widely used analgesic Tramadol, which is molecularly similar to venlafaxine, has been cited as it has SNRI properties which typically are known to affect patients after 3 months or more use in therapeutic doses of 400 mg per day.
Read more about this topic: SSRI Discontinuation Syndrome