Other
- Sensitive Site Exploitation, missions by Navy Special Operations Forces
- Shin Seiki Evangelion, an anime produced by Gainax Animation
- Silk screen effect, a visual phenomenon seen in rear-projection televisions
- Standard Scottish English, a dialect of the English language
- Standard Singapore English, a dialect of the English language
- Sign Supported English, the use of British Sign Language with an English grammar
- Sins of a Solar Empire, a video game created by Ironclad Games
- South-southeast, one of the principal directions on a compass or compass rose, lying at the midpoint between the cardinal direction north and the ordinal direction northwest, see: Boxing the compass
- Spaceship Earth (Epcot), an attraction and icon at Epcot, located in the Walt Disney World Resort
- Sum of squared errors of prediction in statistics
- Safe Shutdown Earthquake, a design factor used in Earthquake engineering
- The Sexual Side Effects, an American post-punk rock band
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