SPTR, an acronym, can represent:
- Scottish Physics Teaching Resources, a resource sharing website for Physics teachers in Scotland.
- Savannah Port Terminal Railroad, terminal railroad in the US state of Georgia
- Silapathar railway station, in the Indian Railways code system
- South Pole TDRSS Relay, a telecommunication system at the Amundsen-Scott South Pole Station; see Amundsen-Scott South Pole Station: Operation
- South Park: Tenorman's Revenge, downloadable video game