Sprengel is a surname, and may refer to:
- Hermann Sprengel (1834–1906), chemist
- Karl or Carl Sprengel (1787–1859), botanist
- Kurt Sprengel (1766–1833), botanist
- Christian Konrad Sprengel (1750–1816), teacher, theologist and naturalist
- Bernhard Sprengel (1899–1985), chocolate manufacturer and art collector