SPPS can refer to:
- Saint Paul Public Schools
- Solid phase peptide synthesis
- Solution precursor plasma spray
- Steam powered preservation society
- South Park Primary School, a primary school in London, United Kingdom
- Schell, Pasveer & Partners, a Dutch environmental consultant firm.
- Scandinavian Plant Physiology Society
- Spectral Parameter Power Series, a method for solving Sturm-Liouville equations