SPOP
Gene Ontology | |
---|---|
Molecular function | • protein binding • ubiquitin protein ligase binding |
Cellular component | • nucleus • nuclear speck • Cul3-RING ubiquitin ligase complex |
Biological process | • protein ubiquitination • proteasomal ubiquitin-dependent protein catabolic process |
Sources: Amigo / QuickGO |
47.68 – 47.76 Mb
95.41 – 95.49 Mb
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Read more about SPOP: Clinical Relevance