Spong is a surname of Gaelic descent, and is an archaic term for a piece of land surrounded by water on three sides. Notable people with this name include:
- Clive Spong, illustrator of children's books
- Hilda Spong (1875–1955), English actress
- John Shelby Spong (born 1931), Episcopal bishop
- Mark W. Spong (born 1952), American roboticist
- Paul Spong (born 1939), New Zealand biologist
- Richard Spong (born 1983), Swedish footballer
- Tyrone Spong (born 1985), Dutch kickboxer
- Walter Brookes Spong (1851–1929), British artist
- William B. Spong, Jr. (1920–1997), Virginia Senator
- Roger Spong (1906–1980), English rugby union player
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