Effects
Along with the Spanish Road's military function it also became an important commercial route. The road also helped the Spanish establish permanent diplomatic contacts along its route, such as permanent embassies in Savoy and the Swiss Cantons that were supervised from Lombardy. When the French Wars of Religion broke out, the Spanish and others used the route to provide personnel and materiel support to French Catholics in their fight against the Protestant pretender to the French throne, Henry of Navarre.
One unintended effect of the route was the circulation of the plague by soldiers and commercial travellers to areas along its length.
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