SPAG9

SPAG9

Identifiers Symbols SPAG9; CT89; HLC-6; HLC4; JIP-4; JIP4; JLP; PHET; PIG6 External IDs OMIM: 605430 MGI: 1918084 HomoloGene: 2954 GeneCards: SPAG9 Gene

Gene Ontology
Molecular function	• JUN kinase binding • kinesin binding • mitogen-activated protein kinase p38 binding
Cellular component	• acrosomal vesicle • cytoplasm • cytosol • integral to membrane • perinuclear region of cytoplasm
Biological process	• activation of JUN kinase activity • spermatogenesis • positive regulation of cell migration • retrograde transport, endosome to Golgi • muscle cell differentiation • positive regulation of neuron differentiation • striated muscle cell differentiation • positive regulation of muscle cell differentiation • protein homooligomerization • negative regulation of protein homodimerization activity
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9043 70834 Ensembl ENSG00000008294 ENSMUSG00000020859 UniProt O60271 Q58A65 RefSeq (mRNA) NM_001130527 NM_001025428 RefSeq (protein) NP_001123999 NP_001020599 Location (UCSC) Chr 17:
49.04 – 49.2 Mb Chr 11:
94 – 94.13 Mb PubMed search

C-jun-amino-terminal kinase-interacting protein 4 is an enzyme that in humans is encoded by the SPAG9 gene.

Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur. The protein encoded by this gene is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility.