Weightlessness
In a microgravity environment such as that provided by a spacecraft in orbit around the Earth, humans experience a sense of "weightlessness." Short-term exposure to microgravity causes space adaptation syndrome, a self-limiting nausea caused by derangement of the vestibular system. Long-term exposure causes multiple health issues. The most significant is bone loss, some of which is permanent, but microgravity also leads to significant deconditioning of muscular and cardiovascular tissues.
Read more about this topic: Spaceflight, Challenges Associated With Spaceflight