SOX2
| Gene Ontology | |
|---|---|
| Molecular function | • transcription regulatory region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • miRNA binding • sequence-specific DNA binding • transcription regulatory region DNA binding |
| Cellular component | • nucleus • transcription factor complex • cytoplasm • cytosol |
| Biological process | • negative regulation of transcription from RNA polymerase II promoter • osteoblast differentiation • eye development • endodermal cell fate specification • positive regulation of neuroblast proliferation • chromatin organization • regulation of transcription, DNA-dependent • cell cycle arrest • response to wounding • regulation of gene expression • glial cell fate commitment • forebrain neuron differentiation • pituitary gland development • adenohypophysis development • cerebral cortex development • male genitalia development • positive regulation of epithelial cell differentiation • forebrain development • olfactory placode formation • response to retinoic acid • somatic stem cell maintenance • inner ear morphogenesis • regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of MAPK cascade • tongue development • negative regulation of neuron differentiation • positive regulation of neuron differentiation • negative regulation of osteoblast differentiation • positive regulation of Notch signaling pathway • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • pigment biosynthetic process • lung alveolus development • neuron fate commitment • inner ear development • diencephalon morphogenesis • negative regulation of epithelial cell proliferation • detection of mechanical stimulus involved in sensory perception of sound • detection of mechanical stimulus involved in equilibrioception • retina morphogenesis in camera-type eye • lens induction in camera-type eye • epithelial tube branching involved in lung morphogenesis • response to growth factor stimulus • negative regulation of canonical Wnt receptor signaling pathway • neuronal stem cell maintenance |
| Sources: Amigo / QuickGO | |
181.43 – 181.43 Mb
34.65 – 34.65 Mb
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids. Sox2 has a critical role in maintenance of embryonic and neural stem cells and holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.
Read more about SOX2: Function and Expression in Pluripotency, Role in Neural Stem Cells, Interactions, Eye Deformities