Nomenclature System
Names of individual SLC members have the following format:
- SLCnXm
where:
- SLC is the root name (SoLute Carrier)
- n = an integer representing a family (e.g., 1-47)
- X = a single letter (A, B, C, ...) denoting a subfamily
- m = an integer representing an individual family member (isoform).
For example SLC1A1 is the first isoform of subfamily A of SLC family 1.
An exception occurs with SLC family 21 (the organic anion transporting polypeptide transporters), which for historical reasons have names in the format SLCOnXm where n = family number, X = subfamily letter, and m = member number.
While the HGNC nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lowercase letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene).
Read more about this topic: Solute Carrier Family
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