Soft laser desorption is laser desorption of large molecules that results in ionization without fragmentation. "Soft" in the context of ion formation means forming ions without breaking chemical bonds. "Hard" ionization is the formation of ions with the breaking of bonds and the formation of fragment ions.
Read more about Soft Laser Desorption: Background
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“When as that Rubie, which you weare,
Sunk from the tip of your soft eare,
Will last to be a precious Stone,
When all your world of Beautie ‘s gone.”
—Robert Herrick (1591–1674)