SNUPN

Identifiers Symbols SNUPN; KPNBL; RNUT1; Snurportin1 External IDs OMIM: 607902 MGI: 1913319 HomoloGene: 4166 GeneCards: SNUPN Gene

Gene Ontology
Molecular function RNA cap binding
protein transporter activity
Cellular component nuclear pore
cytosol
Biological process spliceosomal snRNP assembly
protein import into nucleus
gene expression
RNA metabolic process
ncRNA metabolic process
snRNA import into nucleus
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10073 66069 Ensembl ENSG00000169371 ENSMUSG00000055334 UniProt O95149 Q80W37 RefSeq (mRNA) NM_001042581 NM_178374 RefSeq (protein) NP_001036046 NP_848461 Location (UCSC) Chr 15:
75.89 – 75.92 Mb Chr 9:
56.95 – 56.98 Mb PubMed search

Snurportin-1 is a protein that in humans is encoded by the SNUPN gene.

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.