SNAP25

SNAP25

Identifiers Symbols SNAP25; RIC-4; RIC4; SEC9; SNAP; SNAP-25; bA416N4.2; dJ1068F16.2 External IDs OMIM: 600322 MGI: 98331 HomoloGene: 13311 GeneCards: SNAP25 Gene

Gene Ontology
Molecular function	• SNARE binding • protein binding
Cellular component	• cytoplasm • trans-Golgi network • plasma membrane • membrane • cell junction • growth cone • BLOC-1 complex • SNARE complex • neuron projection • synapse • perinuclear region of cytoplasm • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
Biological process	• neurotransmitter uptake • energy reserve metabolic process • synaptic transmission • neurotransmitter secretion • glutamate secretion • synaptic vesicle docking involved in exocytosis • small molecule metabolic process • regulation of insulin secretion
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6616 20614 Ensembl ENSG00000132639 ENSMUSG00000027273 UniProt P60880 P60879 RefSeq (mRNA) NM_003081 NM_011428 RefSeq (protein) NP_003072 NP_035558 Location (UCSC) Chr 20:
10.2 – 10.29 Mb Chr 2:
136.71 – 136.78 Mb PubMed search

Synaptosomal-associated protein 25 (SNAP-25) is a t-SNARE protein that is encoded by the SNAP25 gene in humans. SNAP-25 is a component of the trans-SNARE complex, which is proposed to account for the specificity of membrane fusion and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.