Small nucleolar RNA SNORA68 (also known as U68) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".
ACA68 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA68 is predicted to guide the pseudouridylation of U4393 of 28S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.
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“Children crawl before they walk, walk before they run—each generally a precondition for the other. And with each step they take toward more independence, more mastery of the environment, their mothers take a step away—each a small separation, a small distancing.”
—Lillian Breslow Rubin (20th century)