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- McNary Field (IATA: SLE), the municipal airport for Salem, Oregon
- NYSE stock exchange code for Sara Lee Corporation
- Schramm–Loewner evolution (same as Stochastic Loewner Evolution), a conformally invariant stochastic process
- Sea Level Equation, the equation that governs the sea level variations in response to the melting of continental ice sheets
- Sea level equivalent
- Seletar Expressway, a major divided highway in the northeast of Singapore
- Separate Legal Entity, type of legal entity with detached accountability
- Shore Line East commuter rail service in Connecticut, USA
- Simple List Extensions, proposed as an extension to existing syndication technologies such as RSS and Atom to make it easier for clients to support the ordering and filtering of lists
- Single loss expectancy in risk analysis
- Sleeper Either Class, a type of railway sleeping car manufactured in Britain
- Sober living environment, facilities used by addicts recovering from substance abuse, which serve as an interim environment between rehab and a return to their former lives
- Societas Linguistica Europaea, a linguistics society
- Spearhead Land Element, the 'Extremely high readiness' infantry battalion of the British armed forces that is first to deploy in anywhere in time of need
- Structured Liberal Education (Stanford University), a department and humanities program for freshmen at Stanford University
- Supporting Leading Edge, a structure of a power kite
- System of linear equations, a collection of linear equations involving the same set of variables. For example
- Acronym for SUSE Enterprise Linux
- In Socionics, a Sensory Logical Extrovert
- Solid-liquid Equilibrium, a phase equilibrium
- The Space Link Extensions of CCSDS
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