Entertainment
- Film
- Slaughter (1972 film), a 1972 film starring Jim Brown and Rip Torn
- Slaughter (2009 film), a 2009 film from After Dark Films
- Music
- Slaughter (band), an American hard rock band
- Slaughter (Canadian band), a Canadian thrash metal band
- Slaughter & the Dogs, a British punk band
- "Slaughter", Billy Preston song used as the theme to the film of the same name
- Sports
- Chicago Slaughter, professional indoor football team
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