Skullduggery may mean:
- Skull Duggery, a character with a reputation as a dangerous racer, from the first episode of the 1967 Speed Racer anime (his name was changed in later episodes, but appearance remained the same).
- Skullduggery (film), a 1970 film starring Burt Reynolds
- Skullduggery (1983 film), a 1983 film
- Skullduggery (board game), winner of one of five "Mensa Select" seals at 2007 Mind Games in Pittsburgh, PA
- Skullduggery (computer game), a 1986 text adventure game
- Skullduggery (album), an album by the band Steppenwolf
- Skull Duggery (rapper), an American rapper formerly of No Limit Records
- Skullduggery (band), a 1980s and 1990s punk band that featured former Social Distortion drummer Bob Stubbs
- Skullduggery (book), by Kathleen Karr