SK3

SK3 (small conductance calcium-activated potassium channel 3) also known as K_Ca2.3 is a protein that in humans is encoded by the KCNN3 gene.

SK3 is a small-conductance calcium-activated potassium channel partly responsible for the calcium-dependent after hyperpolarisation current (I_AHP). It belongs to a family of channels known as small-conductance potassium channels, which consists of three members – SK1, SK2 and SK3 (encoded by the KCNN1, 2 and 3 genes respectively), which share a 60-70% sequence identity. These channels have acquired a number of alternative names, however a NC-IUPHAR has recently achieved consensus on the best names, K_Ca2.1 (SK1), K_Ca2.2 (SK2) and K_Ca2.3 (SK3). Small conductance channels are responsible for the medium and possibly the slow components of the I_AHP.