Causes
Although its etiology is poorly understood, it has been found to be linked to maternal diabetes mellitus, family history of malformations, and maternal cocaine use, suggesting both genetic and environmental factors play a role.
Genetic associations of heterotaxy include:
| Type | OMIM | Gene | Locus |
|---|---|---|---|
| HTX1 | 306955 | ZIC3 | Xq26.2 |
| HTX2 | 605376 | CFC1 | 2q21.1 |
| HTX3 | 606325 | PA26 | 6q21 |
| HTX4 | 613751 | ACVR2B | 992 |
| HTX5 | 270100 | NODAL | 10q22.1 |
Read more about this topic: Situs Ambiguus
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