Adverse Effects
Adverse effects observed with sitaxentan are class effects of endothelin receptor antagonists, and include :
- liver enzyme abnormalities (increased ALT and AST)
- headache
- edema
- constipation
- nasal congestion
- upper respiratory tract infection
- dizziness
- insomnia
- flushing
Because sitaxentan inhibits metabolism of warfarin, a decreased dose of warfarin is needed when co-administered with sitaxentan. This is because warfarin acts to prevent blood from clotting, and if it remains unmetabolized, it can continue to thin the blood.
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