Dose
Simvastatin is a powerful lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. It is used in doses of 5 mg up to 80 mg. Higher doses (160 mg) have been found to be too toxic, while giving only minimal benefit in terms of lipid lowering.
In secondary prevention, 80 mg per day reduced major cardiovascular events by an absolute rate of 1.2% compared with 20 mg per day in a randomized controlled trial.
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