Immune Control
Lipopolysaccharides trigger the immune system to produce proinflammatory cytokines IL-1, IL-6, and tumor necrosis factor (TNF). These peripherally released cytokines act on the brain via a fast transmission pathway involving primary input through the vagus nerves, and a slow transmission pathway involving cytokines originating from the choroid plexus and circumventricular organs and diffusing into the brain parenchyma by volume transmission. Peripheral cytokines may enter the brain directly. They may also induce the expression of other cytokines in the brain that cause sickness behavior. Acute psychosocial stress enhances the ability of an immune response to trigger both inflammation and behavioral sickness.
Read more about this topic: Sickness Behavior
Famous quotes containing the words immune and/or control:
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