Sickles may refer to:
People:
- Carlton R. Sickles (1921-2004), American lawyer and congressman from Maryland
- Daniel Sickles (1819-1914), American politician and Civil War general
- Frederick Ellsworth Sickels or Sickles (1819-1895), American inventor
- Mark D. Sickles (born 1957), American politician
- Nicholas Sickles (1801-1845), U.S. Representative from New York
- Noel Sickles (1910-1982), American commercial illustrator and cartoonist
- Teresa Bagioli Sickles (1836-1867), wife of Daniel Sickles
- William Sickles (1844-1938), American Civil War soldier and Medal of Honor recipient
Places:
- Sickles, Oklahoma, an unincorporated community
- Sickles, an unincorporated community in Hamilton Township, Gratiot County, Michigan