Synthetic Utility
The Sharpless Epoxidation is viable with a large range of primary and secondary olefinic alcohols. Furthermore, with the exception noted above, a given dialkyl tartrate will preferentially add to the same face independent of the substitution on the olefin. To demonstrate the synthetic utility of the Sharpless Epoxidation, the Sharpless group created synthetic intermediates of various natural products: methymycin, erythromycin, leukotriene C-1, and (+)-disparlure.
As one of the few, highly enantioselective reactions during its time, many manipulations of the of the 2,3-epoxyalcohols have been developed.
The Sharpless Epoxidation has been used for the total synthesis of various carbohydrates, terpenes, leukotrienes, pheromones, and antibiotics.
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Famous quotes containing the words synthetic and/or utility:
“In every philosophical school, three thinkers succeed one another in the following way: the first produces out of himself the sap and seed, the second draws it out into threads and spins a synthetic web, and the third waits in this web for the sacrificial victims that are caught in it—and tries to live off philosophy.”
—Friedrich Nietzsche (1844–1900)
“Moral sensibilities are nowadays at such cross-purposes that to one man a morality is proved by its utility, while to another its utility refutes it.”
—Friedrich Nietzsche (1844–1900)