Sharpie may refer to:
- Sharpie (marker), a line of permanent markers
- Sharpies (Australian subculture), members of certain Australian youth gangs in the 1960s and 1970s
- Sharpie (boat), a type of long, narrow sailboat
- Sharp-shinned Hawk, birds that are sometimes referred to as "sharpies"
- Skinheads Against Racial Prejudice