Shackleton is an English surname, and may refer to:
- Ernest Shackleton (1874-1922), Antarctic explorer
- David Shackleton (1863-1938), British cotton worker and trade unionist
- David John Shackleton (born 1948), Vice Admiral of the Royal Australian Navy
- Derek Shackleton (1924-2007), English cricketer
- Edward Shackleton (1911-1994), British geographer and Labour Party politician
- Fiona Shackleton (born 1956) English solicitor for the Royal Family and Paul McCartney
- Greg Shackleton, Balibo Five
- Keith Shackleton (born 1923) British painter of natural history and broadcaster
- Len Shackleton (1922-2000), English footballer
- Nicholas Shackleton (1937-2006), British geologist and climatologist
- Robert Shackleton (actor) (1914-1956), British theatre and film actor
- Robert Shackleton (1919-1986), British French-language philologist and librarian
- Robert Millner Shackleton (1909–2001), British field geologist specialising in East Africa
- Shane Shackleton (born 1982), Australian rugby league player
- D. R. Shackleton Bailey (1917-2005), English scholar of Latin literature
- Richard Shackleton Pope (1793-1884), British architect
- Sam Shackleton, British dubstep music producer
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