SH2B2

SH2B2

Identifiers Symbols SH2B2; APS External IDs OMIM: 605300 MGI: 1345171 HomoloGene: 10309 GeneCards: SH2B2 Gene

Gene Ontology
Molecular function	• signal transducer activity • SH3/SH2 adaptor activity • phospholipid binding • JAK pathway signal transduction adaptor activity
Cellular component	• cytoplasm • cytosol • plasma membrane
Biological process	• signal transduction • blood coagulation • insulin receptor signaling pathway • intracellular signal transduction • regulation of JAK-STAT cascade
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 10603 23921 Ensembl ENSG00000160999 ENSMUSG00000005057 UniProt O14492 Q9JID9 RefSeq (mRNA) NM_020979 NM_018825 RefSeq (protein) NP_066189 NP_061295 Location (UCSC) Chr 7:
101.93 – 101.96 Mb Chr 5:
136.22 – 136.24 Mb PubMed search

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.