SF3B4

SF3B4

Identifiers Symbols SF3B4; AFD1; Hsh49; SAP49; SF3b49 External IDs OMIM: 605593 MGI: 109580 HomoloGene: 22334 GeneCards: SF3B4 Gene

Gene Ontology
Molecular function	• nucleotide binding • RNA binding • protein binding
Cellular component	• nucleoplasm • spliceosomal complex • U12-type spliceosomal complex
Biological process	• RNA splicing, via transesterification reactions • mRNA splicing, via spliceosome • mRNA processing • RNA splicing • gene expression
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10262 107701 Ensembl ENSG00000143368 ENSMUSG00000068856 UniProt Q15427 Q8QZY9 RefSeq (mRNA) NM_005850 NM_153053 RefSeq (protein) NP_005841 NP_694693 Location (UCSC) Chr 1:
149.9 – 149.9 Mb Chr 3:
96.17 – 96.18 Mb PubMed search

Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene.

This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.