SF3B14

SF3B14

Identifiers Symbols SF3B14; HSPC175; Ht006; P14; SAP14; SF3B14a External IDs OMIM: 607835 MGI: 1913305 HomoloGene: 9360 GeneCards: SF3B14 Gene

Gene Ontology
Molecular function	• nucleotide binding • RNA binding
Cellular component	• nucleoplasm • U12-type spliceosomal complex
Biological process	• mRNA splicing, via spliceosome • RNA splicing • gene expression
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 51639 66055 Ensembl ENSG00000115128 ENSMUSG00000037361 UniProt Q9Y3B4 P59708 RefSeq (mRNA) NM_016047 NM_025323 RefSeq (protein) NP_057131 NP_079599 Location (UCSC) Chr 2:
24.29 – 24.3 Mb Chr 12:
4.82 – 4.83 Mb PubMed search

Splicing factor 3B, 14 kDa subunit, also known as SF3B14, is a human gene.

This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site.