Evolution
Serpins were initially believed to be restricted to eukaryote organisms, but have since been found in a number of bacteria and archaea. It remains unclear whether these prokaryote genes are the descendants of an ancestral prokaryotic serpin or the product of lateral gene transfer (genetic transfer between organisms not by evolutionary descent). Rawlings et al. showed that serpins are the most widely distributed and largest family of protease inhibitors.
Read more about this topic: Serine Protease Inhibitors
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