Vascular Smooth Muscle Contraction
Activation of vascular TP receptors has been observed to invariably induce vasoconstriction. The same has been illustrated by in vitro potency and efficacy of TXA2 in inducing constriction of internal mammary arteries. Seratrodast competitively inhibited the contractile response to TXA2 mimetic (analogue) in guinea pig lung parenchymal strips and dog saphenous vein strips. In anesthetized rabbits, Seratrodast abolished the decrease in internal diameter of small pulmonary arteries in response to TXA2 mimetic (analogue), indicating direct role of activation of TP receptors in vascular smooth muscle contraction.
Read more about this topic: Seratrodast, Pharmacodynamics
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