Septo-optic Dysplasia

Septo-optic dysplasia (SOD), also known as de Morsier syndrome is a congenital malformation syndrome made manifest by hypoplasia (underdevelopment) of the optic nerve and absence of the septum pellucidum (a midline part of the brain). Vision in each eye can be unaffected, partially lost, or in some patients, completely absent.

Although not included in the name, hypopituitarism is sometimes included in the definition.

Neuroradiologically, intracranial malformations associated with septo-optic dysplasia include agenesis of the septum pellucidum, schizencephaly, and lobar holoprosencephaly.