SEPT7

SEPT7

Identifiers Symbols SEPT7; CDC10; CDC3; NBLA02942; SEPT7A External IDs OMIM: 603151 MGI: 1335094 HomoloGene: 1354 GeneCards: SEPT7 Gene

Gene Ontology
Molecular function	• structural molecule activity • protein binding • GTP binding
Cellular component	• condensed chromosome kinetochore • stress fiber • nucleus • nucleolus • cytoplasm • spindle • plasma membrane • actin cytoskeleton • microtubule cytoskeleton • apical plasma membrane • midbody • septin complex • cleavage furrow • cilium axoneme • axon terminus • synapse
Biological process	• cytokinesis • mitosis • regulation of embryonic cell shape • protein heterooligomerization • cilium morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 989 235072 Ensembl ENSG00000122545 ENSMUSG00000001833 UniProt Q16181 O55131 RefSeq (mRNA) NM_001011553 NM_001205367 RefSeq (protein) NP_001011553 NP_001192296 Location (UCSC) Chr 7:
35.84 – 35.94 Mb Chr 9:
25.25 – 25.31 Mb PubMed search

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been determined, its high similarity to yeast CDC10 and the high conservative nature of eukaryotic cell cycle machinery suggest a similar role to that of its yeast counterpart. Alternative splicing results in two transcript variants encoding different isoforms.