Selective Internal Radiation Therapy - Agents

Agents

The microspheres themselves are made of glass or resin. Inside the microspheres is the isotope yttrium-90, which has beta-emission with a half-life of 2.6 days. Currently there are 2 types of microspheres: TheraSphere and SIR-Spheres, which differ in their radioactivity per sphere and embolic effect.

Parameter Resin Glass
Trade name SIR-Spheres Therapheres
Manufacturer and location Sirtex Medical, Lane Cover, Australia MDS Nordion, Kanata, Canada
Diameter 20-60 µm 20-30 µm
Specific gravity 1.6 g/dL 3.6 g/dL
Activity per particle 50 Bq 2500 Bq
Number of microspheres per 3 GBq vial 40-80 million 1.2 million
Material resin with bound yttrium glass with yttrium in matrix

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