Surname
- Erasmo Seguin (1782–1857), Texas postmaster, San Antonio Mayor & political figure, Rancher
- Juan Nepomuceno Seguín (1806–1890), Tejano hero of the Texas Revolution
- Edouard Seguin (1812-1880), French physician
- Marc Seguin (1786-1875), French engineer and inventor
- Philippe Séguin (1943-2010), French politician
- Danny Seguin (1948-), retired Ice Hockey Player
- Tyler Seguin, Ice Hockey Player
- Wolfgang Seguin, East German association footballer
- Louis de Seguin, Marquis de Pazzi and former owner of the notable Châteauneuf-du-Pape wine estate Château Fortia
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